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  Biological variation in clinical chemical parameters in green lguanas
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 Ophav:
Nørregård, Rebecka1, Forfatter
Bertelsen, Mads Frost1, Vejleder
Kjeldgaard-Hansen, Mads1, Vejleder
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1Det Biovidenskabelige Fakultet, København, Danmark, diskurs:7002              
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 Abstract: Clinical chemistry is commonly used in veterinary practice as a diagnostic tool and for monitoring progression of diseases. For proper interpretation of measurements obtained from clinical chemical analysis of blood samples, knowledge about normal biological variation is needed. Examples of numbers calculated from studies on biological variation which are used to help the assessment of measurements of clinical chemistry are the index of individuality (IoI) and the critical difference (CD). The index of individuality is used for evaluating how useful population based reference values are to the majority of the population. High IoI values (>1.4) indicate good use of the reference values where as a low IoI (1.4. Calculation of index of individuality was not possible in magnesium and sodium as the nested analysis yielded negative values for the intraindividual variance in these parameters. The critical differences were calculated as percentages and were as follow: ALT 66%, albumin 24%, cholesterol 43%, fructose amine 20%, potassium 39%, total protein 23%, BUN 118%, calcium 14%, creatinine 52%, glucose 43%, lipase 13%, phosphate 46% and uric acid 113%.Proper comparison with previously studies on biological variation is hard because of differences in study designs. The IoI’s calculated in this study fits well with the fact that most IoI’s from previous studies are either low or intermediate for most parameters, however wide ranges of IoI’s has been proposed. In this study there were indications of factors such as body mass may have influenced the outcome of IoI calculation of some parameters. As there were no correction made for these factors IoI’s of this study should be taken as estimates of whether IoI were high or low rather than as absolute values. Comparison with results from a previous study on Dumeril’s monitors shows similar IoI’s for most analytes but there were marked differences in IoI’s for potassium and calcium. Values for critical differences were rather similar in the both reptilian species. Even if CD’s were similar in the two species, further studies in reptilians are needed to investigate whether intraindividual variation changes with disease, for these values to be confidently used.
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Basal

Bogmærk denne post: https://diskurs.kb.dk/item/diskurs:31997:1
 Type: Speciale
Alternativ titel: Biologisk varaiation af klinisk kemiske parameter hos grønne leguaner
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Detaljer

Sprog: English - eng
 Datoer: 2010
 Sider: 57 pages
 Publiceringsinfo: København, Danmark : Institut for Mindre Husdyrs Sygdomme
 Indholdsfortegnelse: -
 Note: Veterinary Medicine, Veterinærmedicin, Final semester, Afsluttende semester
 Type: Speciale
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