Vitamin A, D and E intake and status and associated variables in cystic fibrosis patients
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Brændgaard Kristensen, Camilla1, Forfatter
Mølgaard, Christian1, Vejleder
Pressler, Tania1, Vejleder
1Det Biovidenskabelige Fakultet, København, Danmark, diskurs:18              
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 Abstract: Background: Patients with cystic fibrosis (CF) are at risk of vitamin A, D and E deficiency because of malabsorption despite treatment with pancreatic enzyme replacement and vitamin supplements. Objective: The aim was to describe the vitamin A, D and E intake and serum concentrations in CF patients. Furthermore to investigate if there was a correlation between vitamin A, D and E status and various demographic, anthropometric, biochemical, dietary and functional variables. Design: This observational study evaluated CF patients from the Copenhagen Cystic Fibrosis Centre at Rigshospitalet. Serum values of vitamin A, D and E was compared to reference ranges for healthy individuals. Dietary and supplemental vitamin A, D and E intake was compared with the recommended intake for the general population, CF recommendations and data from the Danish National Survey of Dietary Habits and Physical Activity (DNSDHPA). Results: Vitamin A, D and E status was found to be deficient in respectively 11.4%, 53.6% and 32.2% of the202 CF patients defined as s-retinol = 0.7 ?mol/l, s-25(OH)D <50 nmol/l and ratio s-a-tocopherol:cholesterol+TG <3.1. The age specific normal range for vitamin A was exceeded in 5.4% of the patients. The intake from diet and supplements of a subgroup of 58 CF patients was median (range) 3105 ?g (924-8692) vitamin A, 22.24 ?g (7.38-68.16) vitamin D and 208.09 mg (16.99-408.70) vitamin E. The intake from supplements covered 58%, 77% and 93% of the vitamin A, D and E intake respectively. In regression analysis s-retinol was found to be significantly associated with disease activity (FEV1, CRP and z-score for weight), age, sex and vitamin D and E status, but not the intake of vitamin A. S-25(OH)D was only significantly associated with age and Vitamin A and E status, while s-a-tocopherol as the only status parameter was found to be significantly associated with intake of vitamin E as well as vitamin A and D status, TG and cholesterol. Further more vitamin D status was dependent on season with the highest levels in the summer time. Conclusion: Vitamin A, D and E deficiency was frequent despite of treatment with pancreatic enzymes and an intake of vitamins that followed the CF recommendations. Higher doses of supplements and more time spent in the sun may be needed to reach optimal levels. Vitamin A exceeded normal levels in a group of patients. It is therefore important to assess vitamin status once a year and also when enzyme and supplement regimes are changed to ensure optimal levels.
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 Type: Speciale
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Sprog: English - eng
 Datoer: 2008
 Sider: 47 pages
 Publiceringsinfo: København, Danmark : Institut for Human Ernæring
 Indholdsfortegnelse: -
 Note: Clinical Nutrition, Klinisk Ernæring
 Type: Speciale
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