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  Assessment of spontaneous behaviour as indicator of disease progression and pain in the collagen-induced arthritis mouse model
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 Ophav:
Jensen, Andres Eskjær1, Forfatter
Krohn, Thomas Cæcius1, Vejleder
Mikkelsen, Lars Friis1, Vejleder
Anderson, Ellen Christina1, Vejleder
Dragsted, Nils1, Vejleder
Tilknytninger:
1Det Biovidenskabelige Fakultet, København, Danmark
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 Abstract: The aim of this study was to examine the effect of collagen-induced arthritis on the spontaneous behaviour of mice using LABORAS™ in order to assess disease progression and pain. To elucidate these matters, the study examined if there was a correlation between behaviour and disease progression, as indicated by a widely used clinical score system and as indicated by days from onset of clinical signs. This study found that collagen-induced arthritis in mice had an impact on their spontaneous behaviour expressed by reduced locomotion, climbing and grooming and increased immobility, reaffirming that collagen-induced arthritis in mice is painful and therefore needs intensive monitoring to avoid unnecessary suffering. The changes in behaviour were highly correlated to the day of onset of arthritis and showed some correlation to the clinical disease score system, indicating that pain increases as the disease progresses. The fragility of the collagen-induced arthritis disease model was elaborated and the use of the LABORAS system was enlightened and admonitions uncovered.
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application/pdf / 538KB
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Basal

Bogmærk denne post: https://diskurs.kb.dk/item/diskurs:12676:1
 Type: Speciale
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Detaljer

Sprog: English - eng
 Datoer: 2010
 Sider: 15 pages
 Publiceringsinfo: København, Danmark : Institut for Veterinær Sygdomsbiologi
 Indholdsfortegnelse: -
 Note: Veterinary Medicine, Veterinærmedicin
 Type: Speciale
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